Selected publications

CD4⁺ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy - Franken A*, Bila M*, Mechels A, Kint S, Van Dessel J, Pomella V, Vanuytven S, Philips G, Bricard O, Xiong J, Boeckx B, Hatse S, Van Brussel T, Schepers R, Van Aerde C, Geurs S, Vandecaveye V, Hauben E, Vander Poorten V, Verbandt S, Vandereyken K, Qian J, Tejpar S, Voet T, Clement P* & Lambrechts D* Immunity - 2024. Pubmed

Lower respiratory tract single-cell RNA sequencing and neutrophil extracellular trap profiling of COVID-19-associated pulmonary aspergillosis: a single centre, retrospective, observational study - Feys S, Vanmassenhove S, Kraisin S, Yu K, Jacobs C, Boeckx B, Cambier S, Cunha C, Debaveye Y, Gonçalves S, Hermans G, Humblet-Baron S, Jansen S, Lagrou K, Meersseman P, Neyts J, Peetermans M, Rocha-Pereira J, Schepers R, Spalart V, Starick M, Thevissen K, Van Brussel T, Van Buyten T, Van Mol P, Vandenbriele C, Vanderbeke L, Wauters E, Wilmer A, Van Weyenbergh J, Van De Veerdonk F, Carvalho A, Proost P, Martinod P*, Lambrechts D* & Wauters J* The Lancet Microbe - 2024. PubMed

PD-1^- CD45RA⁺ effector-memory CD8 T cells and CXCL10⁺ macrophages are associated with response to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma - Cappuyns S, Philips G, Vandecaveye V, Boeckx B, Schepers R, Van Brussel T, Arijs I, Mechels A, Bassez A, Lodi F, Jaekers J, Topal H, Topal B, Bricard O, Qian J, Van Cutsem E, Verslype C, Lambrechts D* & Dekervel J* Nature Communications - 2023. PubMed

PARP inhibitor predictive value of the Leuven HRD test compared with Myriad MyChoice CDx PLUS HRD on 468 ovarian cancer patients from the PAOLA-1/ENGOT-ov25 trial - Loverix L*, Vergote I*, Busschaert P, Vanderstichele A, Venken T, Boeckx B, Harter P, Brems H, Van Nieuwenhuysen E, Pignata S, Baert T, Gonzalez-Martin A, Han S, Marth C, Neven P, Colombo N, Berteloot P, Mäenpää J, Olbrecht S, Laga T, Sablon E, Ray-Coquard I, Pujade-Lauraine E, Lambrechts D* & Van Gorp T*. European Journal of Cancer - 2023. PubMed

Single-cell transcriptomics identifies pathogenic T-helper 17.1 cells and pro-inflammatory monocytes in immune checkpoint inhibitor-related pneumonitis - Franken A*, Van Mol P*, Vanmassenhove S, Donders E, Schepers R, Van Brussel T, Dooms C, Yserbyt J, De Crem N, Testelmans D, De Wever W, Nackaerts K, Vansteenkiste J, Vos R, Humblet-Baron S, Lambrechts D* & Wauters E* Journal for ImmunoTherapy Cancer - 2022. PubMed

Nucleosome footprinting in plasma cell-free DNA for the pre-surgical diagnosis of ovarian cancer - Vanderstichele A*, Busschaert P*, Landolfo C, Olbrecht S, Coosemans A, Froyman W, Loverix L, Concin N, Braicu EI, Wimberger P, Van Nieuwenhuysen E, Han SN, Van Gorp T, Venken T, Heremans R, Neven P, Bourne T, Van Calster B, Timmerman D, Lambrechts D, Vergote I. NPJ Genom Med - 2022. PubMed

High-grade serous tubo-ovarian cancer refined with single-cell RNA sequencing: specific cell subtypes influence survival and determine molecular subtype classification - Olbrecht, S., Busschaert, P., Qian, J., Vanderstichele, A., Loverix, L., Van Gorp, T., Van Nieuwenhuysen, E., Han, S., Van den Broeck, A., Coosemans, A., Van Rompuy, A.S., Lambrechts, D. & Vergote, I. -  2021 - Genome Med - PubMed 

A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer - Bassez A, Vos H, Van Dyck L, Floris G, Arijs I, Desmedt C, Boeckx B, Vanden Bempt M, Nevelsteen I, Lambein K, Punie K, Neven P, Garg AD, Wildiers H, Qian J, Smeets A, Lambrechts D – 2021 – Nature Medicine - PubMed -   Read the story behind the paper

Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling on bronchoalveolar lavages. - Wauters E*, Van Mol P*, Garg AD*, Jansen S*, Van Herck Y, Vanderbeke L, Bassez A, Boeckx B, Malengier-Devlies B, Timmerman A, Van Brussel T, Van Buyten T, Schepers R, Heylen E, Dauwe D, Dooms C, Gunst J, Hermans G, Meersseman P, Testelmans D, Yserbyt J, Tejpar S, De Wever W, Matthys P; CONTAGIOUS collaborators, Neyts J, Wauters J, Qian J, Lambrechts D. - 2021 - Cell Research - PubMed

Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity - Vanderbeke L*, Van Mol P*, Van Herck Y*, De Smet F*, Humblet-Baron S*, Martinod K*, Antoranz A, Arijs I, Boeckx B, Bosisio FM, Casaer M, Dauwe D, De Wever W, Dooms C, Dreesen E, Emmaneel A, Filtjens J, Gouwy M, Gunst J, Hermans G, Jansen S, Lagrou K, Liston A, Lorent N, Meersseman P, Mercier T, Neyts J, Odent J, Panovska D, Penttila PA, Pollet E, Proost P, Qian J, Quintelier K, Raes J, Rex S, Saeys Y, Sprooten J, Tejpar S, Testelmans D, Thevissen K, Van Buyten T, Vandenhaute J, Van Gassen S, Velásquez Pereira LC, Vos R, Weynand B, Wilmer A, Yserbyt J, Garg AD, Matthys P, Wouters C, Lambrechts D, Wauters E, Wauters J - 2021 - Nature Communications - PubMed 

A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling. - Qian J, Olbrecht S, Boeckx B, Vos H, Laoui D, Etlioglu E, Wauters E, Pomella V, Verbandt S, Busschaert P, Bassez A, Franken A, Bempt MV, Xiong J, Weynand B, van Herck Y, Antoranz A, Bosisio FM, Thienpont B, Floris G, Vergote I, Smeets A, Tejpar S, Lambrechts D. - 2020 - Cell Research - Pubmed

DNA Methylation-Driven EMT Is a Common Mechanism of Resistance to Various Therapeutic Agents in Cancer. - Galle E, Thienpont B, Cappuyns S, Venken T, Busschaert P, Van Haele M, Van Cutsem E, Roskams T, van Pelt J, Verslype C, Dekervel J and Lambrechts D. - 2020 - Clinical Epigenetics  - Pubmed

DNA methylation repels binding of HIF transcription 1 factors to maintain tumour immunotolerance - D’Anna F*, Van Dyck L*, Xiong J*, Zhao H*, Berrens R, De Smedt J, Bieniasz-Krzywiec P, Chandra V, Schoonkans L, Matthews J, Minnoye L, Qian J, Amorim R, Khorasanizadeh S, De Borre M, Savvides S, Simon C, Carmeliet P, Reik W, Rastinjad F,Mazzone M, Thienpont B, Lambrechts D - 2020 - Genome Biology - Pubmed

The genomic landscape of nonsmall cell lung carcinoma in never smokers. - Boeckx B*, Shahi RB*, Smeets D, De Brakeleer S, Decoster L, Van Brussel T, Galdermans D, Vercauter P, Decoster L, Alexander P, Berchem G, Ocak S, Vuylsteke P, Deschepper K, Lambrechts M, Cappoen N, Teugels E, Lambrechts D, De Greve J. - 2020 - International Journal of Cancer  - Pubmed

Age-related changes in DNA methylation affect renal histology and post-transplant fibrosis. - Heylen L, Thienpont B, Busschaert P, Sprangers B, Kuypers D, Moisse M, Lerut E, Lambrechts D, Naesens M. - 2019 - Kidney International  - Pubmed

Genetic biomarkers in the VEGF pathway predicting response to anti-VEGF therapy in age-related macular degeneration. - Balikova I, Postelmans L, Pasteels B, Coquelet P, Catherine J, Efendic A, Hosoda Y, Miyake M, Yamashiro K; ANGEL study group members, Thienpont B, Lambrechts D - 2019 - BMJ Open Ophalmology - Pubmed

Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy. - Smeets, D.*, Miller, I.S.*, O'Connor, D.P.*, Das, S., Moran, B., Boeckx, B., Gaiser, T., Betge, J., Barat, A., Klinger, R., van Grieken, N.C.T., Cremolini, C., Prenen, H., Mazzone, M., Depreeuw, J., Bacon, O., Fender, B., Brady, J., Hennessy, B.T., McNamara, D.A., Kay, E., Verheul, H.M., Maarten, N., Gallagher, W.M., Murphy, V., Prehn, J.H.M., Koopman, M., Punt, C.J.A., Loupakis, F., Ebert, M.P.A., Ylstra, B., Lambrechts, D.* & Byrne, A.T.* - 2018 - Nature Communications - Pubmed

Phenotype molding of stromal cells in the lung tumor microenvironment. - Lambrechts, D., Wauters, E., Boeckx, B., Aibar, S., Nittner, D., Burton, O., Bassez, A., Decaluwe, H., Pircher, A., Van den Eynde, K., Weynand, B., Verbeken, E., De Leyn, P., Liston, A., Vansteenkiste, J., Carmeliet, P., Aerts, S. & Thienpont, B. - 2018 - Nature Medicine - Pubmed

Ischemia-Induced DNA Hypermethylation during Kidney Transplant Predicts Chronic Allograft Injury. - Heylen, L., Thienpont, B., Naesens, M., Busschaert, P., Depreeuw, J., Smeets, D., Jochmans, I., Monbaliu, D., Pirenne, J., Lerut, E., Ghesquiere, B., Kuypers, D., Lambrechts, D. & Sprangers, B. - 2018 - Journal of the American Society of Nephrology - Pubmed

Integrated genome analysis of uterine leiomyosarcoma to identify novel driver genes and targetable pathways. - Cuppens, T., Moisse, M., Depreeuw, J., Annibali, D., Colas, E., Gil-Moreno, A., Huvila, J., Carpen, O., Zikan, M., Matias-Guiu, X., Moerman, P., Croce, S., Lambrechts, D. & Amant, F. - 2018 - International Journal of Cancer - Pubmed

Chromosomal Instability in Cell-Free DNA as a Highly Specific Biomarker for Detection of Ovarian Cancer in Women with Adnexal Masses. - Vanderstichele, A., Busschaert, P., Smeets, D., Landolfo, C., Van Nieuwenhuysen, E., Leunen, K., Neven, P., Amant, F., Mahner, S., Braicu, E.I., Zeilinger, R., Coosemans, A., Timmerman, D., Lambrechts, D. & Vergote, I. - 2017 - Clinical Cancer Research - Pubmed

It's T Time for Normal Blood Vessels. - Thienpont, B. & Lambrechts, D. - 2017 - Devepmental cell - Pubmed

Amplification of 1q32.1 Refines the Molecular Classification of Endometrial Carcinoma. - Depreeuw, J., Stelloo, E., Osse, E.M., Creutzberg, C.L., Nout, R.A., Moisse, M., Garcia-Dios, D.A., Dewaele, M., Willekens, K., Marine, J.C., Matias-Guiu, X., Amant, F., Lambrechts, D. & Bosse, T. - 2017 - Clinical Cancer Research - Pubmed

Reproductive profiles and risk of breast cancer subtypes: a multi-center case-only study. - Brouckaert, O., Rudolph, A., Laenen, A., Keeman, R., Bolla, M.K., Wang, Q., Soubry, A., Wildiers, H., Andrulis, I.L., Arndt, V., Beckmann, M.W., Benitez, J., Blomqvist, C., Bojesen, S.E., Brauch, H., Brennan, P., Brenner, H., Chenevix-Trench, G., Choi, J.Y., Cornelissen, S., Couch, F.J., Cox, A., Cross, S.S., Czene, K., Eriksson, M., Fasching, P.A., Figueroa, J., Flyger, H., Giles, G.G., Gonzalez-Neira, A., Guenel, P., Hall, P., Hollestelle, A., Hopper, J.L., Ito, H., Jones, M., Kang, D., kConFab, Knight, J.A., Kosma, V.M., Li, J., Lindblom, A., Lilyquist, J., Lophatananon, A., Mannermaa, A., Manoukian, S., Margolin, S., Matsuo, K., Muir, K., Nevanlinna, H., Peterlongo, P., Pylkas, K., Saajrang, S., Seynaeve, C., Shen, C.Y., Shu, X.O., Southey, M.C., Swerdlow, A., Teo, S.H., Tollenaar, R., Truong, T., Tseng, C.C., van den Broek, A.J., van Deurzen, C.H.M., Winqvist, R., Wu, A.H., Yip, C.H., Yu, J.C., Zheng, W., Milne, R.L., Pharoah, P.D.P., Easton, D.F., Schmidt, M.K., Garcia-Closas, M., Chang-Claude, J., Lambrechts, D. & Neven, P. - 2017 - Breast Cancer Research - Pubmed

Tumors smother their epigenome. - Thienpont, B., Van Dyck, L. & Lambrechts, D. - 2016 - Molecular & Cellular Oncology - Pubmed

Tumour hypoxia causes DNA hypermethylation by reducing TET activity. - Thienpont, B., Steinbacher, J., Zhao, H., D'Anna, F., Kuchnio, A., Ploumakis, A., Ghesquiere, B., Van Dyck, L., Boeckx, B., Schoonjans, L., Hermans, E., Amant, F., Kristensen, V.N., Peng Koh, K., Mazzone, M., Coleman, M., Carell, T., Carmeliet, P. & Lambrechts, D. - 2016 - Nature - Pubmed

TET enzymes as oxygen-dependent tumor suppressors: exciting new avenues for cancer management. - Thienpont, B., Galle, E. & Lambrechts, D. - 2016 - Epigenomics - Pubmed

Corrigendum to "Genetic heterogeneity after first-line chemotherapy in high-grade serous ovarian cancer" - Lambrechts, S., Smeets, D., Moisse, M., Braicu, E.I., Vanderstichele, A., Zhao, H., Van Nieuwenhuysen, E., Berns, E., Sehouli, J., Zeillinger, R., Darb-Esfahani, S., Castillo-Tong, D.C., Lambrechts, D. & Vergote, I. - 2016 - European Journal of Cancer - Pubmed

Genetic heterogeneity after first-line chemotherapy in high-grade serous ovarian cancer. - Lambrechts, S., Smeets, D., Moisse, M., Braicu, E.I., Vanderstichele, A., Zhao, H., Van Nieuwenhuysen, E., Berns, E., Sehouli, J., Zeillinger, R., Darb-Esfahani, S., Cacsire Castillo-Tong, D., Lambrechts, D. & Vergote, I. - 2016 - European Journal of Cancer - Pubmed

Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types. - Kar, S.P., Beesley, J., Amin Al Olama, A., Michailidou, K., Tyrer, J., Kote-Jarai, Z., Lawrenson, K., Lindstrom, S., Ramus, S.J., Thompson, D.J., Investigators, A., Kibel, A.S., Dansonka-Mieszkowska, A., Michael, A., Dieffenbach, A.K., Gentry-Maharaj, A., Whittemore, A.S., Wolk, A., Monteiro, A., Peixoto, A., Kierzek, A., Cox, A., Rudolph, A., Gonzalez-Neira, A., Wu, A.H., Lindblom, A., Swerdlow, A., Group, A.S., Australian Cancer, S., BioResource, A., Ziogas, A., Ekici, A.B., Burwinkel, B., Karlan, B.Y., Nordestgaard, B.G., Blomqvist, C., Phelan, C., McLean, C., Pearce, C.L., Vachon, C., Cybulski, C., Slavov, C., Stegmaier, C., Maier, C., Ambrosone, C.B., Hogdall, C.K., Teerlink, C.C., Kang, D., Tessier, D.C., Schaid, D.J., Stram, D.O., Cramer, D.W., Neal, D.E., Eccles, D., Flesch-Janys, D., Edwards, D.R., Wokozorczyk, D., Levine, D.A., Yannoukakos, D., Sawyer, E.J., Bandera, E.V., Poole, E.M., Goode, E.L., Khusnutdinova, E., Hogdall, E., Song, F., Bruinsma, F., Heitz, F., Modugno, F., Hamdy, F.C., Wiklund, F., Giles, G.G., Olsson, H., Wildiers, H., Ulmer, H.U., Pandha, H., Risch, H.A., Darabi, H., Salvesen, H.B., Nevanlinna, H., Gronberg, H., Brenner, H., Brauch, H., Anton-Culver, H., Song, H., Lim, H.Y., McNeish, I., Campbell, I., Vergote, I., Gronwald, J., Lubinski, J., Stanford, J.L., Benitez, J., Doherty, J.A., Permuth, J.B., Chang-Claude, J., Donovan, J.L., Dennis, J., Schildkraut, J.M., Schleutker, J., Hopper, J.L., Kupryjanczyk, J., Park, J.Y., Figueroa, J., Clements, J.A., Knight, J.A., Peto, J., Cunningham, J.M., Pow-Sang, J., Batra, J., Czene, K., Lu, K.H., Herkommer, K., Khaw, K.T., kConFab, I., Matsuo, K., Muir, K., Offitt, K., Chen, K., Moysich, K.B., Aittomaki, K., Odunsi, K., Kiemeney, L.A., Massuger, L.F., Fitzgerald, L.M., Cook, L.S., Cannon-Albright, L., Hooning, M.J., Pike, M.C., Bolla, M.K., Luedeke, M., Teixeira, M.R., Goodman, M.T., Schmidt, M.K., Riggan, M., Aly, M., Rossing, M.A., Beckmann, M.W., Moisse, M., Sanderson, M., Southey, M.C., Jones, M., Lush, M., Hildebrandt, M.A., Hou, M.F., Schoemaker, M.J., Garcia-Closas, M., Bogdanova, N., Rahman, N., Investigators, N., Le, N.D., Orr, N., Wentzensen, N., Pashayan, N., Peterlongo, P., Guenel, P., Brennan, P., Paulo, P., Webb, P.M., Broberg, P., Fasching, P.A., Devilee, P., Wang, Q., Cai, Q., Li, Q., Kaneva, R., Butzow, R., Kopperud, R.K., Schmutzler, R.K., Stephenson, R.A., MacInnis, R.J., Hoover, R.N., Winqvist, R., Ness, R., Milne, R.L., Travis, R.C., Benlloch, S., Olson, S.H., McDonnell, S.K., Tworoger, S.S., Maia, S., Berndt, S., Lee, S.C., Teo, S.H., Thibodeau, S.N., Bojesen, S.E., Gapstur, S.M., Kjaer, S.K., Pejovic, T., Tammela, T.L., Network, G., consortium, P., Dork, T., Bruning, T., Wahlfors, T., Key, T.J., Edwards, T.L., Menon, U., Hamann, U., Mitev, V., Kosma, V.M., Setiawan, V.W., Kristensen, V., Arndt, V., Vogel, W., Zheng, W., Sieh, W., Blot, W.J., Kluzniak, W., Shu, X.O., Gao, Y.T., Schumacher, F., Freedman, M.L., Berchuck, A., Dunning, A.M., Simard, J., Haiman, C.A., Spurdle, A., Sellers, T.A., Hunter, D.J., Henderson, B.E., Kraft, P., Chanock, S.J., Couch, F.J., Hall, P., Gayther, S.A., Easton, D.F., Chenevix-Trench, G., Eeles, R., Pharoah, P.D. & Lambrechts, D.  - 2016 - Cancer Discovery - Pubmed

* equal contribution